HEALthy Brain and Child Development (HBCD) Study - Release 2.1

Investigators

Chambers, C and Nelson, C and Dale, A and Fair, D and Smyser, C and Acheson, A and Bakhireva, L and Bandoli, G and Bell, MA and Berry, O and Bogdan, R and Bosquet Enlow, M and Coles, C and Croff, J and Cutting, L and Dapretto, M and Dean, D and DeMauro, S and Engel, S and Fallin, D and Fox, N and Gao, W and Garavan, H and Georgieff, M and Graham, A and Grant, E and Gregory, K and Hays Grudo, J and Hosig, K and Howell, B and Huang, H and Jones Harden, B and Kable, J and Kana, R and Leeman, L and Levitt, P and Lin, W and Marienfeld, C and Mayer, A and McKelvey, L and Merhar, S and Morris, A and Newsom, C and Norton, E and Osmundson, S and Ou, X and Pekar, J and Peralta-Carcelen, M and Perez-Edgar, K and Poehlmann-Tynan, J and Potter, A and Riggins, T and Rogers, C and Satin, A and Schulyer, A and Shuffrey, L and Smith, B and Smith, L and Spann, M and Sullivan, E and Thomason, M and Vannest, J and Volk, H and Wakschlag, L and Wilson, S and Wisnowski, J and Xiong, Y and Yerby, L and Zgierska, A and Zilverstand, A

Abstract

The HBCD Study Data Release 2.1 includes high-quality baseline and longitudinal data from over 3,500 participants, including minimally processed brain image volumes and tabulated structural magnetic resonance imaging (MRI), diffusion MRI, resting-state fMRI, and electroencephalogram (EEG), as well as data from some of the biospecimens (including genetics), demographics, mental health, physical health, neuro cognition and language, novel technology (wearable sensors), behavior and caregiver-child interactions, pregnancy exposures including substance use, and social and environmental determinants. For neuroimaging assessments, this release contains Visit 2 (0–1 month), Visit 3 (3–9 months), and Visit 4 (9–15 months) data. For non-imaging assessments, this release contains longitudinal data from Visit 1 (prenatal), Visit 2 (0–1 month), Visit 3 (3–9 months), Visit 4 (9–15 months), and Visit 5 (10- 17 months). This data release also includes fixes to several Known Issues and introduces new data elements from some of the abovementioned domains, such as Olink (inflammation) and the Early Regulation in Context Assessment (ERICA). For a detailed description of the fixes to known issues and the new data elements included in this release, visit the 2.1 release notes available athttps://docs.hbcdstudy.org/

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